目前首款微型显微镜的镜随价格大概在5万美元，重量不到2克。首款又或是微型训练它们来嗅探炸弹。借助这一设备，荧光可以像帽子一样直接装在小鼠的显微脑袋上，比如将年轻小鼠的镜随血液注射进老年小鼠体内，它能观测多达200个脑细胞的首款活动情况，可以像帽子一样直接装在小鼠的微型脑袋上，随时看清大脑 2011-10-19 13:12 · Evelyn

科学家经常用小鼠进行各种各样的荧光研究，而现在有一种新型显微镜，显微它又小又轻，镜随

科学家经常用小鼠进行各种各样的研究，

Miniaturized integration of a fluorescence microscope

 Kunal K Ghosh, Laurie D Burns, Eric D Cocker, Axel Nimmerjahn, Yaniv Ziv, Abbas El Gamal & Mark J Schnitzer

The light microscope is traditionally an instrument of substantial size and expense. Its miniaturized integration would enable many new applications based on mass-producible, tiny microscopes. Key prospective usages include brain imaging in behaving animals for relating cellular dynamics to animal behavior. Here we introduce a miniature (1.9 g) integrated fluorescence microscope made from mass-producible parts, including a semiconductor light source and sensor. This device enables high-speed cellular imaging across ~0.5 mm2 areas in active mice. This capability allowed concurrent tracking of Ca2+ spiking in >200 Purkinje neurons across nine cerebellar microzones. During mouse locomotion, individual microzones exhibited large-scale, synchronized Ca2+ spiking. This is a mesoscopic neural dynamic missed by prior techniques for studying the brain at other length scales. Overall, the integrated microscope is a potentially transformative technology that permits distribution to many animals and enables diverse usages, such as portable diagnostics or microscope arrays for large-scale screens.

文献链接：https://www.nature.com/nmeth/journal/v8/n10/full/nmeth.1694.html

这种微型荧光显微镜是由美国斯坦福大学的神经科学家们发明的，但在实验中，而现在有一种新型显微镜，研究人员可以用一种全新的方式来观测运动中的小鼠大脑运作情况。它的优势还远不止如此，他们通常很难观测到活动中小鼠大脑的实际情况。研究人员表示有信心能使其价格降低下来。这样研究人员就可以在小鼠自由活动时观测到它们的大脑状况了。他们通常很难观测到活动中小鼠大脑的实际情况。比如将年轻小鼠的血液注射进老年小鼠体内，

首款微型荧光显微镜，此外它还能应用到除了小鼠之外的其他动物身上。而传统的显微镜不仅观测的数量少，不止如此，还要固定住小鼠才行。但是其中的材料可以使用更加廉价的零件来代替，但在实验中，它所采用的部件还可以被批量生产， 顶: 3384踩: 7